mouse monoclonal IgG1; γ-crystallin Antibody (B-5) is an IgG1 κ mouse monoclonal gamma-crystallin antibody (also designated γ-crystallin antibody) that detects the gamma-crystallin protein of mouse, rat and human origin by WB, IP, IF and ELISA. γ-crystallin Antibody (B-5) is available as both the non-conjugated anti-gamma-crystallin antibody form, as well as multiple conjugated forms of anti-gamma-crystallin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into α, β, and γ families, and the β and γ-crystallins also comprise a superfamily. Crystallins usually contain seven distinctive protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. γ-crystallins are structural proteins in the lens, and they exists as monomers which typically lack connecting peptides and terminal extensions. The γ-crystallins include seven closely related γA, γB, γC, γD, γE, γF, and γG-crystallin, as well as the γN and γS-crystallin genes. The γ-crystallins are differentially regulated after early development, and are involved in cataract formation as a result of either age-related protein degradation or genetic mutation.