mouse monoclonal IgG2b; ERp5 Antibody (G-5) is an IgG2b κ mouse monoclonal ERp5 antibody (also designated Protein Disulfide Isomerase Family A Member 6 antibody, P5 antibody, Thioredoxin Domain Containing 7 (Protein Disulfide Isomerase) antibody, Protein Disulfide Isomerase-Related Protein antibody, Protein Disulfide Isomerase-Associated 6 antibody, Thioredoxin Domain-Containing Protein 7 antibody, Endoplasmic Reticulum Protein 5 antibody, TXNDC7 antibody, or ERP5 antibody) that detects the ERp5 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. ERp5 Antibody (G-5) is available as both the non-conjugated anti-ERp5 antibody form, as well as multiple conjugated forms of anti-ERp5 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Endoplasmic reticulum proteins (ERps) are widely expressed proteins that localize to the ER and may act as proteases, protein disulfide isomerases, thiol-disulfide oxidases or phospholipases. ERp5, also known as PDIA6 (protein disulfide isomerase family A, member 6) or TXNDC7 is a 440 amino acid protein that contains two thioredoxin domains and belongs to the protein disulfide isomerase family. Localized to the melanosome, as well as to the lumen of the endoplasmic reticulum, ERp5 functions to catalyze the rearrangement of disulfide bonds in a variety of different proteins. Via its catalytic activity, ERp5 is able to reduce the disulfide bond that binds MICA to tumor cells, thereby releasing MICA and reducing the rate of tumor expansion. Multiple isoforms of ERp5 exist due to alternative splicing events.