mouse monoclonal IgG1; MARK2 Antibody (B-1) is an IgG1 κ mouse monoclonal MARK2 antibody (also designated MARK2 antibody) that detects the MARK2 protein of human origin by WB, IP, IF and ELISA. MARK2 Antibody (B-1) is available as both the non-conjugated anti-MARK2 antibody form, as well as multiple conjugated forms of anti-MARK2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Microtubule affinity-regulating kinase 2 (MARK2), also known as EMK1 (ELKL motif kinase 1) or Par1b, is a 788 amino acid protein that is a member of the protein kinase superfamily, MARK subfamily. Highly expressed in heart, brain, skeletal muscle and pancreas, MARK2 is essential for the asymmetric development of membrane domains around polarized epithelial cells. Activation of MARK2 by phosphorylation on Thr 208 allows the protein to modulate the building of a columnar versus a hepatic epithelial cell. MARK2 contains one KA1 (kinase-associated) domain, one protein kinase domain and one UBA domain. MARK2 is expressed as 14 isoforms produced by alternative splicing events. Some of these isoforms may function in graft rejection.