In recent years, sophisticated new methods for sedimentation data analysis have opened up new avenues for leveraging AUC technology in a wide range of technology sectors, including life science research, pharmaceutical QC, material, polymer and nano science. In this talk, Borries Demeler will highlight some of the approaches used in his lab to extract ever more information from sedimentation velocity experiments. In this talk he will address ways of accurately characterizing systems at high resolution that are heterogeneous in both size and shape, and present methods for measuring the strength of macromolecular interactions by fitting discrete binding models to whole boundary sedimentation velocity experiments.

Learning Objectives:

• Learn ways to accurately characterize systems at high resolution that are heterogeneous in both size and shape
• Learn approaches used to extract ever more information from sedimentation velocity experiments
• See methods for measuring the strength of macromolecular interactions by fitting discrete binding models to whole boundary sedimentation velocity experiments