Immune escape mechanisms such as the induction/recruitment of immunosuppressive cells and the increased expression of various immunosuppressive molecules including PD-1/PD-1 ligands are essential processes during cancer development and progression, leading to the development of complex immune-suppressive networks in the tumor microenvironment. Thus, high-dimensional immune profiling using CyTOF® technology for single-cell phenotype and function analysis plays an important role to develop more effective cancer immunotherapeutic strategies and to define biomarkers for stratifying responders and non-responders via the detailed analysis of immune responses in cancer patients.

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