Glycosylation plays a significant role in the stability, safety and efficacy of protein therapeutics. As a result, glycan expression profiling is one of the critical quality attributes that must be monitored closely during clone selection in early development.

 

During upstream bioprocessing stages, thousands of samples must be screened monthly. To meet this need, a robust, high-throughput analytical characterization tool that can deliver reliable instrumentation is necessary. Additionally, efficient, user-friendly and flexible data analysis software is needed for large-scale sample analysis.

 

This presentation highlights the reproducibility of high-throughput N-linked glycan separation using capillary electrophoresis (CE) on the BioPhase 8800 system with both manual and automated sample preparation using the Biomek i5 Automated Liquid Handler from Beckman Coulter Life Sciences. Discover how you can reduce the time needed to screen for thousands of therapeutics and make confident decisions faster.

 

Learning Objectives