Early detection is critical for improved survival in melanoma. Melanocytic nevi are extremely common benign tumors that mimic melanoma and are therefore commonly biopsied. Currently, the detection of melanoma is based on histological examination; however, disagreement between pathologists occurs in up to 10-25% of cases. Yet many indeterminate tumors are characterized by low cellularity and purity posing challenges to the currently available molecular technologies. Therefore, spatial genomics technologies for the detection of melanoma are needed to address many of these challenges. This presentation discusses a spatially resolved multiplex RNA analysis of 1,412 genes using formalin-fixed paraffin-embedded melanocytic tumors with the GeoMx™ Digital Spatial Profiler*

*FOR RESEARCH USE ONLY. Not for use in diagnostic procedures.