DATE: February 8, 2017
TIME: 6:00am PT, 9:00 ET

Several regulatory bodies require that animals used in biomedical and behavioral research exposed to procedures that may cause more than momentary or slight pain or distress should be provided with appropriate sedation, analgesia, or anesthesia. However, use of analgesics in certain murine models is a topic of debate, as analgesics have the potential to have an effect on biological responses of an animal.  A common analgesic used in research is the synthetic opiate buprenorphine HCL. Sustained release Buprenorphine (Bup SR) is a sustained-release injectable formulation of buprenorphine that has grown in popularity due to its extended duration of action compared to standard buprenorphine. This presentation will explore the findings of several research reports comparing buprenorphine HCL to sustained release formulations of buprenorphine with regards to effects on experimental data and postsurgical condition in mice.

Learning Objectives:

• Identify the benefits and disadvantages of the use of buprenorphine (HCL and sustained release) analgesia in a murine model
• Describe methods to evaluate postsurgical condition in mice