DATE: April 26, 2017
TIME: 9:00AM PT, 12:00PM ET

Biopsies from non-small cell lung cancer (NSCLC) and colorectal adenocarcinoma generally produce small, heterogeneous samples with limited tumor content in a large background of normal or wild type cells. Current mutation testing platforms offer a wide range of analytical sensitivity. Despite considerable progress, analytical challenges remain to be resolved, such as the need for reliable detection of low abundance somatic mutations, particularly in small specimens with a low percentage of tumor cells. 
In this webinar, Dr. Darryl Irwin from Agena Bioscience will present the recent advances which enable a limit of detection of 1% using iPLEX® HS chemistry on the MassARRAY® System. iPLEX HS chemistry is uniquely suited for the detection of low frequency mutations from highly fragmented and low quality specimens from FFPE, FNA, and cytology smears. 
Dr. Bobbie Sutton from The Medical Foundation will share results from two recent clinical research studies, both of which utilized iPLEX HS Panels targeted for the detection of low abundance mutations from pulmonary and colorectal adenocarcinoma.

Learning Objectives:

• Understand both the need for detecting low abundance mutations and the challenges of working with heterogeneous solid tumor samples
• Learn how the iPLEX® HS Chemistry enables detection of mutations as low as 1% allele frequency from heterogeneous solid tumor samples