September 19, 2024 | 10 AM EDT, 7AM PDT, 4 PM CEST

A Tandem LC Workflow for Maximizing Mass Spectrometer Utilization in Proteomics

Sponsored by: Thermo Fisher Scientific
Speakers

Event Date & Time
Date: September 19, 2024
Time: 10 AM EDT, 7 AM PDT, 4 PM CEST
Abstract
The sample throughput of high-sensitivity liquid chromatography-mass spectrometry (LC-MS) based proteomics analysis is restricted by the pressure limitations of LC and column hardware, with some methods wasting as much as 50% of the method cycle time outside of MS acquisition. Traditional routes for boosting throughput include shorter columns and gradients, higher flow rates, and using trap-and-elute workflows – all of which introduce trade-offs in sensitivity and proteome depth.
 
The Thermo Scientific™ Vanquish™ Neo tandem direct injection workflow leverages hardware innovations and software intelligence to eliminate method overhead while maintaining data quality across nano, capillary, and micro-flow LC-MS.
 
In this webinar experts from Evotec and Bayer will showcase how they implemented the tandem direct injection workflow for their proteomics work. Dr. Nagarjuna Nagaraj will present on how Evotec is using tandem direct injection with nano-LC columns packed in-house to boost sample throughput of their  chemoproteomics screening pipeline, while Dr. Alexander Boychenko from Bayer will discuss how his lab is using a micro-flow tandem direct injection approach to analyze plasma samples for translational proteomics.
 
Learning Objectives
  • See how minimizing LC-MS method overhead can accelerate sample throughput while maintaining proteome depth
  • Discover how labs are using tandem direct injection for chemoproteomics and translational proteomics applications
  • Learn how to implement tandem direct injection in your proteomics workflow
 
 
Webinars will be available for unlimited on-demand viewing after live event.