The nature of work in the clinical core lab has changed over the years from beakers of liquids, specimens and compounds on countertops to sophisticated equipment with prepackaged reagents and electronic services and software packages. Because the testing technology and environment has changed, the response to flexibility needed to change.  Culminating with its openning in 2015, Geisinger Medical Laboratories had the opportunity to design and build a new Laboratory Medicine Building.  Early in the design phase, it was deemed critical to identify the factors driving practice change and incorporate lab-based solutions to address these factors.