In this webinar, we will briefly introduce Vizgen’s Vizgen® MERSCOPE® Platform for spatial transcriptomics. Following this introduction, we will showcase the capabilities of MERSCOPE in deciphering the molecular and cellular features of both mouse and human brain tissue under physiological and pathological conditions. We leveraged the vast gene repertoire of a 960-plex gene panel to achieve unprecedented resolution in neuronal and non-neuronal cell types across disparate mouse brain regions, enabling the molecular and cellular features underpinning various anatomical structures to be uncovered. In addition, by profiling brain samples from normal and AD patient, we could identify cell-type and regions specific molecular changes associated with AD pathogenesis.

 

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