The new technology improves upon previous organs-on-chips by using digital manufacturing, six different 3D-printing inks, and ultra-sensitive sensors. So far, scientists have been able to design organs-on-chips for lungs, hearts, tongues, and intestines.
The 3D-printed heart-on-a-chip, also called a cardiac microphysiological device, can be used to track beating heart tissue, making it easier to study contractile strength as well as how cardiac tissue reacts to drugs and toxins, without relying on animal studies.
"Researchers are often left working in the dark when it comes to gradual changes that occur during cardiac tissue development and maturation because there has been a lack of easy, non-invasive ways to measure the tissue functional performance," said Lind. "These integrated sensors allow researchers to continuously collect data while tissues mature and improve their contractility. Similarly, they will enable studies of gradual effects of chronic exposure to toxins."
The newest advances in 3D-printing technology in the present study are the epitome of the future of precision medicine. Soon, scientists will be able to design organs-on-chips to specifically match a certain diseases or individual’s cells, making it infinitely easier to treat diseases like cardiomyopathy and many others.
Source: Harvard John A. Paulson School of Engineering and Applied Sciences
Images: Johan Lind, Disease Biophysics Group/Lori K. Sanders, Lewis Lab/Harvard University