Fast-tracking drugs in a safe and effective way can eventually save the lives of many from life-threatening diseases. New research at Simon Fraser University proves just that particularly in the treatment of viral infections and cancer.
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"That process has been intensive and challenging, limiting and preventing the discovery of new drug therapies,” says chemist James Britton of the latest study.
"The reduction in time and cost of synthesis will vary, depending on the individual nucleoside analogue, but we have examples where we cut a 20-plus step synthesis, which takes several months to complete at the very least, down to three or four steps, which would only take a week or so.”
"This is clearly a critical factor when it comes to treating newly evolved viruses like SARS-CoV-2 (COVID-19)."
Findings were published in the journal Science and describes new drug discovery methods involving nucleoside analogues.
"This entirely new approach builds in opportunities to diversify these drug scaffolds and should inspire new and unusual nucleoside analogue drug discoveries," says Britton.
Source: Science Daily