From being a promising yet underexplored approach in the 1990s, mRNA therapeutics have evolved dramatically. The discovery of chemical modifications to overcome mRNA’s instability and immunotoxicity enabled these therapeutics to reach clinical trials and the forefront of modern medicine. The platform’s scalability, rapid production and relatively straightforward manufacturing process mean that mRNA therapeutics are a powerful alternative to traditional small molecule drugs and DNA technology.
Enzymes are a vital tool that make in vitro transcription possible and refine the reaction products to generate highly pure, homogeneous mRNA. In this ebook, we provide an in-depth review into:
- The critical stages of mRNA synthesis
- The enzymes that drive mRNA synthesis
- Optimising your enzyme performance
- Yielding high-quality mRNA products
Download the 18-page ebook now.