The PEI study is utilizing the highly successful new direct-acting antiviral hepatitis C drugs (90-97% cure sucess) in a correctional facility that has a 23% infection rate of hepatitis C. The study's goals are twofold; scientists plan to reduce the prevalence of hepatitis C infections in the facility as well as see how the the new medication protects patients against reinfection. The new drugs have few side effects and can be taken orally, making them much better candidates for use in correctional facitlities than previous treatments, which were "given intravenously over long periods of time, with side effects including pain, fatigue and low blood counts" (Medical Xpress).
Ongoing research focused on providing a vaccine for hepatitis C continues and was discussed in an August journal article in Current Opinion in Immunology. Since hepatitis C largely contributes to chronic liver disease, the goal of hepatitis C vaccine research is specifically preventing recurring infections, rather than to "induce sterilizing immunity" (Current Opinion in Immunology). Decreasing the overall burden of chronic liver disease is a priority.
Current potential vaccines undergoing clinical trials include:
- non-structural hepatitis C viral proteins that induce CD8+ T cell immunity
- recombinant hepatitis C viral envelope proteins that are targeted by neutralizing antibodies
Check out the video below to learn more about the pathology of a hepatitis C infection.
Source: Medical Xpress