Nontyphoidal Salmonella serotypes, such as S. Enteritidis, do not cause as severe disease as S. Typhi and are normally not fatal. The disease is characterized by diarrhea, abdominal cramps, vomiting and nausea and typically lasts up to 7 days in healthy individuals. In immunocompromised individuals, the disease can be fatal if not treated with antibiotics. Salmonella passes into the stomach where it binds to receptors on the lining of the intestine and is taken up by the cells. It is able to evade the host immune system by using our own cells to travel to other parts of the body such as the liver or spleen. The bacteria will replicate in the liver and released back into the intestine and released into the environment through feces.
Researchers from Arizona State University describe a unique group of nontyphoidal Salmonella, known as Salmonella Typhimurium ST313, which has emerged as a fatal cause of bacteremia in young children as well as HIV-infected adults in sub-Saharan Africa. These isolates appear to have originated from a multidrug resistant clinical isolate of S. Typhi. While S. Typhi isolates are only able to infect humans, it appears the ST131 isolates have undergone a genome reduction that also allows them to infect non-human hosts. In their experiments, they demonstrated that one isolate from the ST131 group was able to cause lethal and invasive disease in mice where the bacteria was found to colonize the spleen, lymph nodes and gall bladder. The isolate also displayed resistance to low levels of pH, indicating its ability to survive passage through the acidic environment of the stomach.
The authors of this study warn that this isolate, technically identified as a S. Typhimurium ST313, may be evolving towards becoming a more human-specific “typhoid like” pathogen. ST313 infections do not result in symptoms typically associated with gastroenteritis. These isolates are a number one cause of sepsis in sub-Saharan Africa, which is often fatal. Treatment of these infections is also challenging because these isolates are often resistant to more than one type of antibiotic; therefore new treatment options are needed. This study, with the use of the mouse animal model, provides insight into how ST313 has evolved as well as how these isolates may cause disease in humans. More research needs to be done in order to develop better prevention and treatment strategies for those affected, specifically in developing countries.
Sources: Food Safety News, PLOS Neglected Tropical Diseases, Centers for Disease Control and Prevention, Salmonella.org, About Education