That balance is very important to the pathogenicity of an infection. It’s been shown that the acquisition of metals confers virulence in animal models of bacterial infection. Mammalian hosts will start withholding metals in response to microbial infection in an effort to starve the microbe.
Staphylopine is a small molecule that gets exported from the cell and captures transition metals in the extracellular space. The metals get then taken back into the cell by a special channel, where they then provide the nutrients needed for pathogenicity. Based on all of the evidence, it would seem that Staphylopine is quite a versatile metal carrier (a metallophore) that contributes significantly to staphylococcal virulence.
"Remarkably, a few years ago we found that many, taxonomically unrelated, bacteria can release high concentrations of a wide variety of D-amino acids to the environment. Therefore, D-histidine might be just one D-amino acid of many that could serve as a building block for novel staphylopine-like molecules," said Felipe Cava, of MIMS/Umeå University.
Characterizing staphylopine; figuring out how it is assembled, as well as how gets transported may now pave the way for the creation of a new strategy to fight pathogenic bacteria - targeting their need for metals.
Interestingly, staphylopine resembles nicotianamine closely. Nicotianamine is a molecule found in all plants that ensures the delivery of essential metals from where they are collected in the roots to the aerial organs. The discovery of a comparable metal scavenger in three kingdoms of life (eukaryotes, archaea and now bacteria) would indicate there may be an ancient origin for this kind of molecule.
Sources: Science - G.Ghssein et al, AAAS, Science - E. Nolan