Immunology News: Brain Cells Boost Damage Caused by Alzheimer's Risk Variant & more...

Thu, 21 Nov 2024 02:23:31 -0800

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Brain Cells Boost Damage Caused by Alzheimer's Risk Variant

Sometimes there are slightly different versions, or sequences of genes. There are several versions of the apolipoprotein E (APOE) gene, for example. One of them, called APOE4, has been linked to a much higher risk of developing Alzheimer's disease, and carriers often have worse forms of the disease compared to ...

Lack of Dietary Zinc Can Promote Acinetobacter Lung Infections

New research has shown that a lack of dietary zinc can boost the chances of a lung infection caused by Acinetobacter baumannii bacteria; these pathogens are a major reason why people on ventilators get sick with pneumonia. This study has found a connection between molecules that promote inflammation and A ...

A Genetic Deficiency That Raises Susceptibility to Many Types of Flu

There are many processes and proteins that help the body fight a flu infection. One of them is known as IFITM3. Researchers have now shown that this protein can help prevent viruses from mutating after they have infected a new host. But some people are deficient ...

Lactic Acid Alters Antitumor Function in Immune Cells

Tumors find different ways to avoid immune cell detection and proliferate in their environment. Antitumor immune cells will initially recognize and target the growing tumor; however, different mutations and adaptive mechanisms allow the cancer to persist. For example, it is well documented that tumors secrete ...

Energy Demand Creates Distinct Mitochondria

Mitochondria are ancient organelles within mammalian cells that are believed to have derived from free-floating bacteria. Scientists speculate that our primitive mammalian cells engulfed this organelle to better function and survive. As time went on, this organelle became necessary for the mammalian cell’s ...

UPCOMING WEBINARS

Checkpoint molecules, Tregs and induction of anti-tumor immunity

Dr. Vijay Kuchroo - Director, The Gene Lay Institute of Immunology and Inflammation
Brigham and Women's Hospital, Harvard Medical School

Expression of co-inhibitory receptors or “checkpoint” molecules, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory receptors on CD4+ T cells promotes autoimmunity while sustained overexpression on CD8+ T cells promotes T cell dysfunction or exhaustion, leading to impaired ability to clear chronic ...

DEC 04, 2024 8:30 AM PST

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