This group is an open forum to discuss cancer, research, prevention, causes and rehabilitation. Millions of humans are diagnosed with cancer every day. Research is absolutely crucial!
Recent activity in this group:
“Genetics of cancer: Non-coding DNA can finally be decoded
Cancer is a disease of the genome resulting from a combination of genetic modifications, or mutations. We inherit from our parents strong or weak predispositions to developing certain kinds of cancer; in addition, we also accumulate new mutations in our cells throughout our lifetime. Although the genetic origins of cancers have been studied for a long time, researchers were not able to measure the role of non-coding regions of the genome until now.
The team was able to identify two kinds of non-coding mutations that have an impact on the development of colorectal cancer. They found, on one hand, hereditary regulatory variants that are not active in healthy tissue, but are activated in tumors and seem to contribute to cancer progression. It shows that the genome we inherit not only affects our predisposition towards developing cancer, but also has an influence on its progression. On the other hand, the researchers identified effects of acquired mutations on the regulation of gene expression that affect the genesis and progression of colorectal tumors.
'The elements responsible for the development and progression of cancers located in the non-coding genome are as important as those found in the coding regions of the genome. Therefore, analyzing genetic factors in our whole genome, and not only in the coding regions as it was done before, gives us a much more comprehensive knowledge of the genetics behind colorectal cancer,' explains Halit Ongen, the lead author of this study. 'We applied this completely innovative methodology to colorectal cancer, but it can be applied to understand the genetic basis of all sorts of cancers,' underlines Professor Dermitzakis.
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“Join us as the world gets ready for Soccer!
Let’s help it make its way to all of the lab walls! Keep track of all of the teams (and your favorite) with the Enzo Score Card. Share this if you are a soccer fan :) (or just like the idea ).
“"It’s estimated that somewhere between 50 and 70% of all protein encoding genes are under the control of MicroRNAs themselves."