mouse monoclonal IgG1; Ankyrin G Antibody (463) is an IgG1 κ mouse monoclonal Ankyrin G antibody (also designated Ankyrin 3 antibody, or ANK3 antibody) that detects the Ankyrin G protein of mouse, rat and human origin by WB, IP, IF and IHC(P). Ankyrin G Antibody (463) is available as both the non-conjugated anti-Ankyrin G antibody form, as well as multiple conjugated forms of anti-Ankyrin G antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Members of the Ankyrin family of proteins mediate the attachment of integral membrane proteins to the cytoskeleton. ANK1, ANK2 and ANK3 genes encode for the proteins in this family, Ankyrin-1 (also designated Ankyrin R), Ankyrin B and Ankyrin G, respectively. The proteins are structured similarly, each composed of an N-terminal domain with multiple ankyrin repeats, a highly conserved central spectrin binding domain and C-terminal regulatory domains which are susceptible to the most variance. Both Ankyrin B and Ankyrin G are essential for normal neuronal functions. Ankyrin G was originally identified localized to the nodes of Ranvier and axon initial segments where it was found to mediate normal neuronal sodium channel function. Ankyrin G, named for its giant size and general expression, exhibits tissue-specific alternative mRNA processing. The two largest protein isoforms are expressed only in nervous tissue, with additional smaller isoforms found in an array of other tissues including lung, kidney, spleen, liver and heart.