mouse monoclonal IgG1; Clathrin HC Antibody (TD.1) is an IgG1 κ mouse monoclonal Clathrin HC antibody (also designated Clathrin antibody, CLTC antibody, clathrin heavy chain antibody) that detects the Clathrin HC protein of broad species origin by WB, IP, IF and IHC(P). Clathrin HC Antibody (TD.1) is available as both the non-conjugated anti-Clathrin HC antibody form, as well as multiple conjugated forms of anti-Clathrin HC antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Clathrin is a major cytosolic coat protein in pits and vesicles originating from the plasma membrane and the trans-Golgi network. In receptor-mediated endocytosis, receptor proteins are englufed by clathrin-coated vesicles. Clathrin is composed of three heavy chains and three light chains which associate non-covalently to form a triskelion structure. Clathrin heavy chain (HC) is composed of a terminal globular domain, a distal segment and a proximal segment containing a light chain binding site. The proximal segment of the Clathrin HC protein is essential for interactions between clathrin heavy chains and light chains which result in the formation of the triskelion structure.