mouse monoclonal IgG1; casein kinase IIα Antibody (1AD9) is an IgG1 κ mouse monoclonal casein kinase IIα antibody (also designated casein kinase IIα antibody or casein kinase 2 alpha antibody) that detects casein kinase IIα of mouse, rat and human origin by WB, IP, IF and IHC(P). casein kinase IIα Antibody (1AD9) is available as the non-conjugated anti-casein kinase IIα antibody form, as well as multiple conjugated forms of anti-casein kinase IIα antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Casein kinase I (also designated CKI) and casein kinase II (CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. Casein kinase I family members, which include casein kinase Iα, Iγ, Iδ and Ie, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. Casein kinase II is usually expressed as a tetrameric complex consisting of either an α2β2 or an αα'β2 structure. The α catalytic subunit is stimulated by the β regulatory subunit, which undergoes autophosphorylation. Casein kinase II activity is high in the cytosol and nucleus of proliferating and differentiating cells. Casein kinase II is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.