mouse monoclonal IgG1; casein kinase IIβ Antibody (6D5) is an IgG1 κ mouse monoclonal casein kinase II beta antibody (also designated Casein Kinase 2 Beta antibody, Casein Kinase 2 Beta Polypeptide antibody, Casein Kinase II Subunit Beta antibody, Protein G5a antibody, CK II Beta antibody, Phosvitin antibody, CK2N antibody, Ckb1 antibody, Ckb2 antibody, G5A antibody, Casein Kinase II Beta Subunit antibody, CSNK2B antibody, CSK2B antibody, or CK2B antibody) that detects the casein kinase II beta protein of mouse, rat and human origin by WB, IP, IF and IHC(P). casein kinase IIβ Antibody (6D5) is available as both the non-conjugated anti-casein kinase II beta antibody form, as well as multiple conjugated forms of anti-casein kinase II beta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Casein kinase I (also designated CKI) and casein kinase II (CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. Casein kinase I family members, which include casein kinase Iα, Iγ, Iδ and Ie, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an α2β2 or an αα'β2 structure. The a catalytic subunit is stimulated by the β regulatory subunit, which undergoes autophosphorylation. Casein kinase II activity is high in the cytosol and nucleus of proliferating and differentiating cells. Casein kinase II is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.