mouse monoclonal IgG2b; Annexin I Antibody (EH17a) is an IgG2b κ mouse monoclonal Annexin I antibody (also designated ANXA1 antibody, Calpactin-2 antibody, Chromobindin-9 antibody, Lipocortin I antibody or Annexin A1 antibody) that detects the Annexin I protein of mouse, rat and human origin by WB, IP, IF and IHC(P). Annexin I Antibody (EH17a) is available as both the non-conjugated anti-Annexin I antibody form, as well as multiple conjugated forms of anti-Annexin I antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The annexin family of calcium-binding proteins is composed of at least ten mammalian genes and is characterized by a conserved core domain which binds phospholipids in a Ca2+-dependent manner and a unique amino terminal region which may confer binding specificity. The interaction between these proteins and biological membranes have led to the hypothesis that they are involved in cellular trafficking processes such as endocytosis, exocytosis and cellular adhesion. Annexin I, alternatively referred to as lipocortin, has been implicated as a mediator of the anti-inflammatory response produced by glucocorticoids and as an inhibitor of cPLA2, a potent mediator of inflammation. Annexin II, also called p36, has been shown to exist as a monomer or a heterotetramer, complexed with the S-100-related protein p11. This complex is termed calpactin I. In the tetrameric form, Annexin II is an efficient substrate of the PKC family and Src pp60.