IFN-γRβ (MOB-47) | Santa Cruz Biotechnology
hamster monoclonal IgG; IFN-γ induces a variety of biological responses, such as antiviral, antiproliferative and immunomodulatory activity in sensitive cells. Activation of the IFN-γ receptor (IFN-γR) leads to autophosphorylation of the Janus kinases JAK1 and JAK2, and the nuclear translocation of the transcription factors Stat1α p91 and Stat1β p84. The IFN-γR is composed of at least two chains, designated IFN-γRα and IFN-γRβ, respectively (7–9). Although expression of IFN-γRα is sufficient for ligand binding, it alone does not confer responsiveness to IFN-γ. Concomitant expression of IFN-γRα and IFN-γRβ is required for transcriptional activation of IFN-γ-inducible genes. The IFN-γRβ chain, also called AF-1, is 332 and 337 amino acids in length in mouse and human, respectively, and may represent the signal transducing component of the IFN-γR.
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