mouse monoclonal IgG1; 15-LO Antibody (B-7) is an IgG1 κ mouse monoclonal 15-LO antibody (also designated LOX15 antibody, Arachidonate 15-Lipoxygenase antibody, 15-LOX-1 antibody, Polyunsaturated Fatty Acid Lipoxygenase ALOX15 antibody, Arachidonate 12-Lipoxygenase Leukocyte-Type antibody, Arachidonate Omega-6 Lipoxygenase antibody, Hepoxilin A3 Synthase Alox15 antibody, 15-LOX antibody, LOG15 antibody, 15-Lipoxygenase Type 1 antibody, or 15-Lipooxygenase-1 antibody) that detects the 15-LO protein of mouse, rat and human origin by WB, IP, IF and ELISA. 15-LO Antibody (B-7) is available as both the non-conjugated anti-15-LO antibody form, as well as multiple conjugated forms of anti-15-LO antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.