mouse monoclonal IgG2a; Cytokeratin 6/75 Antibody (H-6) is an IgG2a κ mouse monoclonal Cytokeratin 6/75 antibody (also designated KRT6 antibody, Keratin 6 antibody, KRT75 antibody, or Keratin 75 antibody) that detects the Cytokeratin 6/75 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Cytokeratin 6/75 Antibody (H-6) is available as both the non-conjugated anti-Cytokeratin 6/75 antibody form, as well as multiple conjugated forms of anti-Cytokeratin 6/75 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The α-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, aid in the characterization of malignant tumors. In humans, multiple isoforms of Cytokeratin 6 (6A–6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Cytokeratin 75, also designated, K6HF in humans maps to the same genetic loci. In the companion layer of the hair follicle, Cytokeratin 75 is an element of keratin intermediate filaments.