mouse monoclonal IgG1; GABAB R1 Antibody (D-2) is an IgG1 κ mouse monoclonal GABAB R1 antibody (also designated GABR1 antibody, Gamma-Aminobutyric Acid Type B Receptor Subunit 1 antibody, GPRC3A antibody, Gamma-Aminobutyric Acid (GABA) B Receptor 1 antibody, GABABR1 antibody, GABA-B Receptor 1 antibody, GABA-B Receptor antibody, GABA-B-R1 antibody, GABBR1-3 antibody, GABA-BR1 antibody, HGB1a or GB1 antibody) that detects the GABAB R1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. GABAB R1 Antibody (D-2) is available as both the non-conjugated anti-GABAB R1 antibody form, as well as multiple conjugated forms of anti-GABAB R1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In the central nervous system (CNS), gamma-aminobutyric acid (GABA) is the main main inhibitory neurotransmitter that functions to regulate neuronal firing. GABA exerts its effects through two different kinds of receptors: ionotropic receptors (GABAA R and GABAC R), which produce fast inhibitory signals, and metabotropic receptors (GABAB R), which produce slow inhibitory signals. The GABAB R receptor is a heterodimer that consists of two multi-pass membrane proteins, designated GABAB R1 and GABAB R2, both of which belong to the G protein-coupled receptor family and are highly expressed in brain tissue. Together, GABAB R1 and GABAB R2 play a crucial role in the fine-tuning of inhibitory synaptic transmissions and are implicated in slow wave sleep, muscle relaxation, hippocampal long-term potentiation and antinociception events. Both GABAB R1 and GABAB R2 are regulated by G proteins that have a variety of functions, including activation of potassium channels, inhibition of adenylyl cyclase (A cyclase) activity and modulation of inositol phospholipid hydrolysis.