mouse monoclonal IgG2a; Filamin 1 Antibody (E-3) is an IgG2a κ mouse monoclonal Filamin 1 antibody (also designated FLNA antibody, or filamin A antibody) that detects the Filamin 1 protein of mouse, rat and human origin by WB, IP, IF and IHC(P). Filamin 1 Antibody (E-3) is available as both the non-conjugated anti-Filamin 1 antibody form, as well as multiple conjugated forms of anti-Filamin 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Caldesmon, Filamin 1, Nebulin and Villin are differentially expressed and regulated Actin binding proteins. Both muscular (CDh) and non-muscular (CDl) forms of Caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and Myosin. CDh is expressed predominantly on thin filaments in smooth muscle, whereas CDl is widely expressed in non-muscle tissues and cells. Filamin 1, which is ubiquitously expressed and exists as a homodimer, functions to crosslink Actin to filaments. Nebulin is a large filamentous protein specific to muscle tissue that may function as a ruler for filament length. Several isoforms of Nebulin are produced by alternative exon usage. Villin is Ca2+-regulated and is the major structural component of the brush border of absorptive cells.