mouse monoclonal IgG2b; Sos 1 Antibody (A-9) is an IgG2b κ mouse monoclonal Sos 1 antibody (also designated SOS Ras/Rac Guanine Nucleotide Exchange Factor 1 antibody, Gingival Fibromatosis Hereditary 1 antibody, Son Of Sevenless Homolog 1 antibody, SOS-1 antibody, GF1 antibody, HGF antibody, Son Of Sevenless Homolog 1 (Drosophila) antibody, Guanine Nucleotide Exchange Factor antibody, GINGF antibody, or GGF1 antibody) that detects the Sos 1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. Sos 1 Antibody (A-9) is available as both the non-conjugated anti-Sos 1 antibody form, as well as multiple conjugated forms of anti-Sos 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The superfamily of GTP-binding proteins, of which Ras proteins are prototypes, has been implicated in a broad range of biological activities. Studies have identified a family of guanine nucleotide-releasing factors (GRFs) that activate Ras in mammalian cells and an "adapter" protein (Sem 5/GRB2) that appears to mediate the interaction of GRFs with activated receptor molecules. Ras-GRF p140 promotes nucleotide exchange on ras p21s but not on other members of the Ras gene superfamily. In addition, three mammalian homologs of the Drosophila Ras-GRF, son of sevenless (Sos), have been described. These include two from mouse, m Sos 1 and m Sos 2, and one from human, h Sos. Vav p95 has been reported to function as a GRF in activation of Ras by the T cell receptor and has been reported to have a domain similar to that of Dbl p115, which is a GRF specific for CDC42Hs. Subsequent to activation, Ras appears to interact with Raf, thereby activating the MAP kinase phosphorylation pathway.