mouse monoclonal IgG1; α-actinin Antibody (H-2) is an IgG1 κ mouse monoclonal alpha-actinin antibody (also designated ACTN1 antibody, Actinin 1 antibody, Alpha actinin 1 antibody or Cytoskeletal Alpha-actinin antibody) that detects the alpha-actinin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. α-actinin Antibody (H-2) is available as both the non-conjugated anti-alpha-actinin antibody form, as well as multiple conjugated forms of anti-alpha-actinin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins. There are four tissue-specific α-actinins, namely α-actinin-1, α-actinin-2, α-actinin-3 and α-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each α-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding α-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.