mouse monoclonal IgG1; SNAP 25 Antibody (SP12) is an IgG1 κ mouse monoclonal SNAP 25 antibody (also designated SNAP25 antibody, SNP25 antibody, Resistance To Inhibitors Of Cholinesterase 4 Homolog antibody, Synaptosomal-Associated Protein 25 antibody, RIC-4 antibody, RIC4 antibody, SEC9 antibody, or SNAP antibody) that detects the SNAP 25 protein of broad species origin by WB, IP, IF, IHC(P) and ELISA. SNAP 25 Antibody (SP12) is available as both the non-conjugated anti-SNAP 25 antibody form, as well as multiple conjugated forms of anti-SNAP 25 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Syntaxins were originally thought to be docking proteins, but have now been categorized as anchoring proteins that anchor themselves to the cytoplasmic surfaces of cellular membranes. Syntaxins have been shown to bind to various proteins involved in exocytosis, including VAMPs (vesicle-associated membrane proteins), NSF (N-ethylmaleimide-sensitive factor), SNAP 25, SNAPs (soluble NSF attachment proteins) and synaptotagmin. VAMPs, also designated synaptobrevins, including VAMP-1 and VAMP-2, and synaptotagmin, a protein that may function as an inhibitor of exocytosis, are vesicular proteins. SNAPs, including α- and γ-SNAP, are cytoplasmic proteins that bind to a membrane receptor complex composed of VAMP, SNAP 25 and syntaxin. SNAPs mediate the membrane binding of NSF, which is essential for membrane fusion reactions. An additional protein designated synaptophysin may regulate exo-cytosis by competing with SNAP 25 and syntaxins for VAMP binding.