mouse monoclonal IgG1; RBP-Jκ Antibody (E-7) is an IgG1 κ mouse monoclonal RBP-J kappa antibody (also designated SUH antibody, Recombination Signal Binding Protein For Immunoglobulin Kappa J Region antibody, IGKJRB antibody, RBP-J antibody, RBPJK antibody, Recombining Binding Protein Suppressor Of Hairless antibody, RBP-J Kappa antibody, IGKJRB1 antibody, RBP-JK antibody, RBPSUH antibody, CBF-1 antibody, CBF1 antibody, KBF2R antibody, Suppressor Of Hairless Homolog (Drosophila) antibody, Suppressor Of Hairless Homolog antibody, H-2K Binding Factor-2 antibody, or AOS3 antibody) that detects the RBP-J kappa protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. RBP-Jκ Antibody (E-7) is available as both the non-conjugated anti-RBP-J kappa antibody form, as well as multiple conjugated forms of anti-RBP-J kappa antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Recombination signal binding protein Jκ (RBP-Jκ), also designated KBF2 or CBF1, is the mammalian homolog of the Drosophila suppressor of hairless (Su(H)), a protein involved in the development of the peripheral nervous system. RBP-Jκ is ubiquitously expressed in mammalian tissues and is involved in the regulation of gene expression. RBP-Jκ has been shown to directly interact with the intercellular domain of the cell surface receptor Notch 1. Proteolytically cleaved Notch 1 translocates to the nucleus, where it binds DNA-bound RBP-Jκ and activates transcription of target genes. These genes include NFκB p52 and the Epstein-Barr virus (EBV) protein EBNA-2, both of which contain RBP-Jκ-binding sequences within their promoter regions.