mouse monoclonal IgG2a; Dhh Antibody (F-9) is an IgG2a κ mouse monoclonal Dhh antibody (also designated Dhh antibody) that detects the Dhh protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Dhh Antibody (F-9) is available as both the non-conjugated anti-Dhh antibody form, as well as multiple conjugated forms of anti-Dhh antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Drosophila segment polarity gene hedgehog (hh) encodes a precursor protein which undergoes autocleavage to generate amino- and carboxy-terminal peptides. Both proteins are secreted and appear to function in embryonic and imaginal disc patterning. Several vertebrate homologs of Drosophila hh have been identified. These include Sonic hedgehog (Shh) (alternatively designated Vhh-1), Desert hedgehog (Dhh) and Indian hedgehog (Ihh). Each contain amino terminal signal peptides and apparently function as secreted proteins involved in the mediation of various cell-cell interactions. Shh resembles Drosophila hh in that it is processed to generate an amino terminal secreted peptide that is retained at or near the cell surface and a carboxy terminal glycosylated more diffusible peptide.