mouse monoclonal IgG1; κB-Ras1 Antibody (E-3) is an IgG1 κ mouse monoclonal kappa B-Ras1 antibody (also designated κB-Ras1 antibody) that detects the kappa B-Ras1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. κB-Ras1 Antibody (E-3) is available as both the non-conjugated anti-kappa B-Ras1 antibody form, as well as multiple conjugated forms of anti-kappa B-Ras1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Small guanosine triphosphatases, typified by the mammalian Ras proteins, play major roles in the regulation of numerous cellular pathways. IκB-interacting Ras-like proteins, κB-Ras1 and κB-Ras2, belong to a subclass of evolutionarily conserved Ras-like proteins that differ from other Ras proteins in containing amino acids at positions 12 and 61 that are similar to those present in the oncogenic forms of Ras. These Ras-like proteins, κB-Ras1 and κB-Ras2, interact with the PEST domains of IκBα and IκBβ and decrease their rate of degradation. κB-Ras2 shows 71% identity to κB-Ras1. In cells, κB-Ras proteins are associated only with NFκB:IκBβ complexes and therefore may provide an explanation for the slower rate of degradation of IκBβ compared with IκBα.