mouse monoclonal IgG2a; Calumenin Antibody (F-8) is an IgG2a κ mouse monoclonal Calumenin antibody (also designated Crocalbin antibody or CALU antibody) that detects the Calumenin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Calumenin Antibody (F-8) is available as both the non-conjugated anti-Calumenin antibody form, as well as multiple conjugated forms of anti-Calumenin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Caluminin is a 315 amino acid Ca2+-binding member of the CREC, EF-hand protein family. Calumenin is a secreted protein that contains six Ca2+-binding (EF-hand) motifs and is expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus. In the presence of Ca2+, Calumenin interacts with serum amyloid P component (SAP) and, together, they may play a role in the immunological defense system and participate in amyloidosis, the pathological formation of amyloid deposits in different types of tissues. Calumenin has an inhibitory effect on the vitamin K-dependent g-carboxylation system which converts vitamin K-dependent proteins to Gla-containing proteins. Calumenin may also be involved in the pathophysiology of thrombosis and/or wound healing by acting in an autocrine or paracrine manner.