mouse monoclonal IgG1; UCH-L1 Antibody (C-4) is an IgG1 κ mouse monoclonal UCH-L1 antibody (also designated Ubiquitin C-Terminal Hydrolase L1 antibody, Ubiquitin Carboxyl-Terminal Esterase L1 (Ubiquitin Thiolesterase) antibody, Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 antibody, Neuron Cytoplasmic Protein 9.5 antibody, Ubiquitin Thioesterase L1 antibody, or Ubiquitin Thiolesterase antibody) that detects the UCH-L1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. UCH-L1 Antibody (C-4) is available as both the non-conjugated anti-UCH-L1 antibody form, as well as multiple conjugated forms of anti-UCH-L1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. UCH-L1 (ubiquitin C-terminal hydrolase) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. UCH-L1 is expressed in brain neurons. Examination of specific brain regions reveals expression in all areas tested, particularly in the substantia nigra. UCH-L1 represents 1-2% of total soluble brain protein. Its occurrence in Lewy bodies and its function in the proteasome pathway make it a compelling candidate gene in Parkinson disease. The gene which encodes UCH-L1 maps to human chromosome 4p13. The 230 amino acid human UCH-L3 protein is 54% identical to that of UCH-L1. UCH-L3 is the predominant thiol protease and has high-affinity binding sites for ubiquitin.