mouse monoclonal IgG2a; Relaxin Receptor 1 Antibody (3E3) is an IgG2a κ mouse monoclonal Relaxin Receptor 1 antibody (also designated Relaxin Receptor 1 antibody) that detects the Relaxin Receptor 1 protein of human origin by WB, IP, IF and ELISA. Relaxin Receptor 1 Antibody (3E3) is available as the non-conjugated anti-Relaxin Receptor 1 antibody. G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). Relaxin Receptor 1, also known as Relaxin/insulin-like family peptide receptor 1, RXFP1, LGR7 or RXFPR1, is a leucine-rich repeat G protein-coupled receptor that binds Relaxins and INSL3 (insulin-like peptide 3). Expressed in brain, placenta, uterus, kidney, prostate, testis, adrenal, heart, ovary and skin, Relaxin Receptor 1 localizes to the cell membrane and contains ten LRR (leucine-rich repeats) and an LDL-receptor class A domain. Upon Relaxin or INSL3 binding to Relaxin Receptor 1, adenylate (A) cyclase is activated, leading to an increased intracellular concentration of cAMP. cAMP is a key intracellular regulator; it mediates the activities of numerous hormones, including ACTH, Glucagon and epinephrine, and plays an important role in modulating cellular activity. Due to alternative splicing events, two Relaxin Receptor 1 isoforms are expressed.