mouse monoclonal IgG2a; BCAR3 Antibody (3G4) is an IgG2a κ mouse monoclonal BCAR3 antibody (also designated BCAR3 antibody) that detects the BCAR3 protein of human origin by WB, IP and ELISA. BCAR3 Antibody (3G4) is available as the non-conjugated anti-BCAR3 antibody. BCAR3 (breast cancer anti-estrogen resistance 3, also designated AND-34 in murine; a novel SH2-containing protein 2 or NSP2, and SH2D3B) overexpression is a characteristic of antiestrogen resistance in human ZR-75-1 breast cancer cells. The deduced 825-amino acid BCAR3 protein contains a Src homology 2 (SH2) domain and shares homology to yeast CDC48. A 3.4-kb BCAR3 transcript is present in heart, placenta, skeletal muscle, spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and tamoxifen-resistant cancer cell lines. BCAR3 acts as a regulator of R-Ras to mediate the level of insulin receptor substrate 1 (IRS-1) in MCF-7 and ZR-75-1 breast cancer cell lines. BCAR3 also interacts with p130Cas to enhance Src activation and cell migration.