Reviews
Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.
Santa Cruz Biotechnology
ICAT (5C6) | Santa Cruz Biotechnology
mouse monoclonal IgG1; ICAT Antibody (5C6) is an IgG1 κ mouse monoclonal ICAT antibody (also designated ICAT antibody) that detects the ICAT protein of mouse, rat and human origin by WB, IP and ELISA. ICAT Antibody (5C6) is available as the non-conjugated anti-ICAT antibody. ICAT interacts directly with β-catenin and interferes with the Wnt signaling pathway. Specifically, ICAT prevents the interaction of β-catenin with TCF-4 and inhibits β-catenin--TCF-4-mediated transactivation. The negative regulatory effect of ICAT on the Wnt signaling pathway appears to inhibit tumor cell proliferation. ICAT also induces G2 arrest followed by cell death in colorectal tumor cells. The ectopic induction of ICAT inhibits the expression of β3 Tubulin and thus neuronal differentiation in embryonal carcinoma P19 cells. Structural characteristics of ICAT include a three-helix bundle and a C-terminal tail. The gene encoding human ICAT maps to chromosome 1p36.22.
More Scientific Products from Santa Cruz Biotechnology
Opens in a new window
Opens an external site
Opens an external site in a new window