mouse monoclonal IgG2b; Parkin Antibody (PRK8) is an IgG2b κ mouse monoclonal Parkin antibody (also designated PRKN antibody, PARK2 antibody, or parkin RBR E3 ubiquitin protein ligase antibody) that detects the Parkin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. Parkin Antibody (PRK8) is available as both the non-conjugated anti-Parkin antibody form, as well as multiple conjugated forms of anti-Parkin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Parkin is a zinc-finger protein that is related to ubiquitin at the amino terminus. The wild type Parkin gene, which maps to human chromosome 6q25.2-27, encodes a 465 amino acid full-length protein that is expressed as multiple isoforms. Mutations in the Parkin gene are responsible for autosomal recessive juvenile Parkinson's disease and commonly involve deletions of exons 3-5. In humans, Parkin is expressed in a subset of cells of the basal ganglia, midbrain, cerebellum and cerebral cortex, and is subject to alternative splicing in different tissues. Parkin expression is also high in the brainstem of mice, with the majority of immunopositive cells being neurons. The Parkin gene has been identified in a diverse group of organisms including mammals, birds, frog and fruit flies, suggesting that analogous functional roles of the Parkin protein may have been highly conserved during the course of evolution. The Parkin Antibody (PRK8) is also broadly reactive with a wide range of mammalian species, making it an important reagent for molecular biology research.