mouse monoclonal IgG1; HPV18 E7 Antibody (F-7) is an IgG1 κ mouse monoclonal HPV18 E7 antibody (also designated Human Papillomavirus E7 antibody, HPV antibody, Human papillomavirus type 18 antibody, HPV18 Protein E7 antibody, or E7 antibody) that detects the HPV18 E7 protein. HPV18 E7 Antibody (F-7) is available as both the non-conjugated anti-HPV18 E7 antibody form, as well as multiple conjugated forms of anti-HPV18 E7 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group, while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.