mouse monoclonal IgG2b; ICSBP Antibody (E-9) is an IgG2b κ mouse monoclonal ICSBP antibody (also designated Interferon consensus sequence-binding protein (ICSBP) antibody, ICSBP1 antibody, Interferon regulatory factor 8 antibody, Interferon (IFN) regulatory factor (IRF) family transcription factor 8 antibody, IRF-8 antibody, myeloid cell maturation related transcription factor antibody, or myeloid progenitor monocyte lineage mediator antibody) that detects the ICSBP protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. ICSBP Antibody (E-9) is available as both the non-conjugated anti-ICSBP antibody form, as well as multiple conjugated forms of anti-ICSBP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. ICSBP (Interferon (IFN) consensus sequence-binding protein, Interferon regulatory factor 8; IRF-8) is a transcription factor that is important for IFN-γ-mediated signaling during dendritic cell and macrophage differentiation. ICSBP physically interacts with TRAF6 (between amino acid residues 356 and 305), and this interaction of ICSBP with TRAF6 modulates TLR signaling and may contribute to the cross-talk between IFN-γ and TLR signal pathways. ICSBP antagonizes Bcr/Abl by downregulation of Bcl-2. ICSBP is known to interact with chromatin, and bind PU.1 in macrophages. ICSBP belongs to the IFN regulatory factor (IRF) family that also includes IRF-1, IRF-2, and ISGF-3. These proteins are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of IFN-α and IFN-β.