mouse monoclonal IgG1; IDS Antibody (B-5) is an IgG1 κ mouse monoclonal IDS antibody (also designated IDS antibody) that detects the IDS protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. IDS Antibody (B-5) is available as both the non-conjugated anti-IDS antibody form, as well as multiple conjugated forms of anti-IDS antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. IDS (Iduronate 2-sulfatase), also known as SIDS, is a 550 amino acid protein that localizes to the lysosome and belongs to the sulfatase family. Expressed in lung, liver, kidney and placenta, IDS uses calcium as a cofactor to catalyze the hydrolysis of select sulfate groups on dermatan sulfate, heparan sulfate and heparin and, via this catalytic activity, is essential for the lysosomal degradation of both dermatan and heparan sulfate. Defects in the gene encoding IDS are the cause of mucopolysaccharidosis type 2 (MPS2), more commonly known as Hunter syndrome, which is characterized by skeletal deformities, hepatosplenomegaly and progressive cardiopulmonary deterioration, as well as neurological damage and, in some cases, death. IDS exists as two alternatively spliced isoforms, designated long and short.