mouse monoclonal IgG1; MtRPOL Antibody (B-1) is an IgG1 κ mouse monoclonal MtRPOL antibody (also designated MtRPOL antibody) that detects the MtRPOL protein of human origin by WB, IP, IF and ELISA. MtRPOL Antibody (B-1) is available as both the non-conjugated anti-MtRPOL antibody form, as well as multiple conjugated forms of anti-MtRPOL antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The circular mitochondrial genome contains 37 genes that encode the RNA constituents of the mitochondrial translational apparatus. Gene expression in mitochondria relies upon several nuclear genes that encode protein components required for transcription and translation of MtDNA-encoded genes, as well as protein and RNA components necessary for MtDNA replication. Mitochondrial RNA polymerase (MtRPOL) modulates gene expression in the mitochondria by providing the RNA primers for replication/initiation. It also participates in the maintenance and propagation of the mitochondrial genome. Genes involved in the replication and expression of MtRPOL may be candidates for various human disorders. MtRPOL consists of 1,230 amino acid residues, the sequence of which demonstrates substantial homology with sequences corresponding to mitochondrial RNA polymerases from lower eukaryotes and to RNA polymerases from several bacteriophages.