mouse monoclonal IgG1; GIT1 Antibody (A-1) is an IgG1 κ mouse monoclonal GIT1 antibody (also designated GIT ArfGAP 1 antibody, G Protein-Coupled Receptor Kinase Interacting ArfGAP antibody, Cool-Associated And Tyrosine-Phosphorylated Protein antibody, G Protein-Coupled Receptor Kinase-Interactor antibody, ARF GTPase-Activating Protein GIT1 antibody, GRK-Interacting Protein 1 antibody, ARF GAP GIT1 antibody, CAT-1 antibody, CAT1 antibody, or G Protein-Coupled Receptor Kinase Interactor antibody) that detects the GIT1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. GIT1 Antibody (A-1) is available as both the non-conjugated anti-GIT1 antibody form, as well as multiple conjugated forms of anti-GIT1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade. GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking. GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling.