mouse monoclonal IgG1; MTF-1 Antibody (H-6) is an IgG1 κ mouse monoclonal MTF-1 antibody (also designated MTF-1 antibody) that detects the MTF-1 protein of human origin by WB, IP, IF and ELISA. MTF-1 Antibody (H-6) is available as both the non-conjugated anti-MTF-1 antibody form, as well as multiple conjugated forms of anti-MTF-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain (2-3). The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.