mouse monoclonal IgG1; ASA Antibody (H-5) is an IgG1 κ mouse monoclonal ASA antibody (also designated ASA antibody) that detects the ASA protein of human origin by WB, IP, IF and ELISA. ASA Antibody (H-5) is available as both the non-conjugated anti-ASA antibody form, as well as multiple conjugated forms of anti-ASA antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. ASA (arylsulfatase A), also known as Cerebroside-sulfatase, ARSA or MLD, is a 507 amino acid lysosomal protein that belongs to the sulfatase family. Functioning as a homodimer at a neutral pH and as a homooctamer at an acidic pH, ASA uses magnesium as a cofactor to catalyze the H2O-dependent hydrolysis of cerebroside 3-sulfate to cerebroside and sulfate. Defects in the gene encoding ASA are a cause of metachromatic leukodystrophy (MLD), an intralysosomal storage disease that is characterized by ataxias, dementia, seizures, spastic tetraparesis and, ultimately, death. Additionally, defects in ASA activity are associated with multiple sulfatase deficiency (MSD), a disorder that results in decreased activity of all known sulfatases and is generally characterized by metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.