mouse monoclonal IgG1; Adducin γ Antibody (G-2) is an IgG1 κ mouse monoclonal Adducin gamma antibody (also designated gamma adducin antibody or ADD3 antibody) that detects the Adducin gamma protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Adducin γ Antibody (G-2) is available as both the non-conjugated anti-Adducin gamma antibody form, as well as multiple conjugated forms of anti-Adducin gamma antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Adducins are a family of cytoskeleton proteins encoded by three genes (α, β, γ). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin α is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin α and Adducin γ is ubiquitous in contrast to the restricted expression of Adducin β. Adducin β is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.